SCHEMBL7747281

SCHEMBL7747281

O=C(Nc1ccc(C[C@H](NC(=O)C2C[C@@H]3CCCCC3CN2S(=O)(=O)c2cc(Cl)cc(Cl)c2)C(=O)O)cc1)c1c(Cl)cncc1Cl

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 20/20 0.80
ITGB1 P05556 9/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5201119 0.96 ITGA4 (0.80) ITGA4ITGB1
SCHEMBL6302014 0.96 ITGA4 (0.80) ITGA4ITGB1
SCHEMBL5201112 0.96 ITGA4 (0.80) ITGA4ITGB1
SCHEMBL6302016 0.96 ITGA4 (0.80) ITGA4ITGB1
SCHEMBL6476268 0.89 ITGA4 (0.70) ITGA4ITGB1
SCHEMBL5201410 0.89 ITGA4 (0.87) ITGA4ITGB1
SCHEMBL5203708 0.89 ITGA4 (1.00) ITGA4ITGB1
SCHEMBL6476751 0.89 ITGA4 (0.69) ITGA4ITGB1
SCHEMBL6487038 0.89 ITGA4 (0.69) ITGA4ITGB1
SCHEMBL6477907 0.89 ITGA4 (0.69) ITGA4ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6855708-B2 N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors MERCK & CO., INC. (US) 2005-02-15 US disclosed
US-6855708-B2 N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors MERCK & CO., INC. (US) 2005-02-15 US disclosed