Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.73 |
| ▸ | RAB9A | P51151 | 8/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | APAF1 | O14727 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14426546 | 0.87 | NPC1 (0.73) | NPC1RAB9AKMT2AMAPTTP53 | |
| SCHEMBL4248100 | 0.86 | KCNK3 (0.69) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL28622654 | 0.85 | RAB9A (0.93) | NPC1RAB9AKMT2AMAPTFKBP5 | |
| SCHEMBL30369807 | 0.85 | NPC1 (1.00) | NPC1RAB9AKMT2AMAPTLMNA | |
| SCHEMBL4254257 | 0.85 | NPC1 (1.00) | NPC1RAB9AKMT2AMAPTLMNA | |
| SCHEMBL97523 | 0.84 | NPC1 (0.60) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL12443604 | 0.84 | NPC1 (0.73) | NPC1RAB9AKMT2AMAPTTP53 | |
| SCHEMBL15177192 | 0.84 | NPC1 (0.67) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL7813309 | 0.83 | CYP1A2 (0.76) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL7295519 | 0.83 | NPC1 (0.66) | NPC1RAB9AKMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | disclosed |