SCHEMBL7748569

SCHEMBL7748569

CC(=O)Nc1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7748567 1.00 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL7747316 0.99 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL7747313 0.99 BDKRB2 (1.00) BDKRB2
SCHEMBL7839197 0.92 BDKRB2 (0.85) BDKRB2
SCHEMBL7839194 0.92 BDKRB2 (0.85) BDKRB2
Hydrochloric Acid SCHEMBL7747799 0.91 BDKRB2 (0.85) BDKRB2
Hydrochloric Acid SCHEMBL7747802 0.91 BDKRB2 (0.85) BDKRB2
SCHEMBL7748662 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL7748660 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL7748335 0.90 BDKRB2 (0.88) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0622361-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 2001-10-04 EP disclosed
US-6169095-B1 FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES IN THE EYE, SUCH AS ALLERGY, INFLAMMATION AND PAIN OF THE EYE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
US-5563162-A CAN BE ADMINISTERD FOR THE TREATMENT OF ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASES, SHOCK OR PAIN IN ANIMALS AND HUMANS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-08 US disclosed