Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.83 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.83 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.83 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.83 |
| ▸ | TNF | P01375 | 14/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007597 | 0.91 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7746632 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL29441528 | 0.89 | TNF (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6691621 | 0.89 | TNF (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6688721 | 0.88 | TNF (0.82) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6692796 | 0.87 | TNF (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6098458 | 0.85 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL15015502 | 0.85 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL1193946 | 0.85 | TNF (0.73) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL825856 | 0.85 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |