SCHEMBL7749503

SCHEMBL7749503

COC(=O)COc1ccc(O[SiH](c2ccccc2)c2ccccc2)c(C(C)(C)C)c1C(=O)OC(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 2/20 0.38
PLA2G1B P04054 1/20 0.37
POLB P06746 2/20 0.36
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP1A2 P05177 1/20 0.34
ACLY P53396 1/20 0.33
LMNA P02545 2/20 0.33
CYP2C9 P11712 2/20 0.32
HPGD P15428 1/20 0.32
CYP2C19 P33261 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
TSHR P16473 1/20 0.32
MTNR1A P48039 1/20 0.32
MTNR1B P49286 1/20 0.32
GRM6 O15303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7754186 0.76 MEN1 (0.46) KDM4EMEN1KMT2AALDH1A1MAPT
SCHEMBL19979782 0.70 ALDH1A1 (0.50) KDM4EMEN1KMT2AALDH1A1MAPT
SCHEMBL7749499 0.69 KDM4E (0.36) KDM4EMEN1KMT2AALDH1A1MAPT
SCHEMBL10154342 0.64 NPSR1 (0.59) KDM4EMEN1KMT2AALDH1A1MAPT
SCHEMBL10506317 0.64 SMN1; SMN2 (0.60) KDM4EMEN1KMT2AALDH1A1MAPT
SCHEMBL7753595 0.64 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2CYP1A2CYP2C9CYP2C19
SCHEMBL17707469 0.63 PRMT5 (0.49) KDM4EKMT2AALDH1A1POLBHTT
SCHEMBL22656552 0.63 POLB (0.50) KDM4EMEN1KMT2AALDH1A1MAPT
SCHEMBL20235270 0.62 ALDH1A1 (0.52) MEN1KMT2AALDH1A1MAPTHTT
SCHEMBL31425872 0.62 ALDH1A1 (0.52) MEN1KMT2AALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20010029239-A1 New herbicidal compositions CRAMP MICHAEL COLIN (GB) 2001-10-11 US disclosed
WO-2001047863-A2 NEW HERBICIDAL COMPOSITIONS AVENTIS CROPSCIENCE SA (FR) 2001-07-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010029239-A1 New herbicidal compositions DDT, CYP1B1, CYP4X1 KDM4E 200/4885MEN1 4657/4885KMT2A 651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.