SCHEMBL7749874

SCHEMBL7749874

CC(N)C/C=C/c1cncnc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.56
CHRNB2 P17787 3/20 0.41
CHRNA4 P43681 3/20 0.41
HRH4 Q9H3N8 3/20 0.32
HRH3 Q9Y5N1 3/20 0.32
ALDH1A1 P00352 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
GLA P06280 1/20 0.32
CYP1A2 P05177 1/20 0.32
NFKB1 P19838 1/20 0.32
THPO P40225 1/20 0.32
GRIK1 P39086 1/20 0.31
GRIK2 Q13002 1/20 0.31
LMNA P02545 1/20 0.31
APEX1 P27695 1/20 0.31
BLM P54132 1/20 0.31
AKT1 P31749 1/20 0.31
CHRNB4 P30926 1/20 0.30
CHRNA3 P32297 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7738081 1.00 HTR2A (0.56) HTR2ACHRNB2CHRNA4HRH4HRH3
SCHEMBL13334636 1.00 HTR2A (0.56) HTR2ACHRNB2CHRNA4HRH4HRH3
Hydrochloric Acid SCHEMBL3324772 0.98 HTR2A (0.55) HTR2ACHRNB2CHRNA4HRH4HRH3
Hydrochloric Acid SCHEMBL3324767 0.98 HTR2A (0.55) HTR2ACHRNB2CHRNA4HRH4HRH3
SCHEMBL4422413 0.81 HTR2A (0.37) HTR2ACHRNB2CHRNA4
SCHEMBL4422410 0.81 HTR2A (0.37) HTR2ACHRNB2CHRNA4
SCHEMBL3128193 0.79 CHRNB2 (0.68) HTR2ACHRNB2CHRNA4MEN1KMT2A
SCHEMBL3020951 0.79 CHRNB2 (0.68) HTR2ACHRNB2CHRNA4MEN1KMT2A
SCHEMBL10398580 0.79 CHRNB2 (0.68) HTR2ACHRNB2CHRNA4MEN1KMT2A
SCHEMBL9519584 0.79 CHRNB2 (0.68) HTR2ACHRNB2CHRNA4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801527-A4 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS REYNOLDS TOBACCO CO R (US) 2001-09-05 EP disclosed
EP-0801527-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1997-10-22 EP disclosed
WO-1996020600-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-07-11 WO disclosed