Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.38 |
| ▸ | FPR2 | P25090 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7751002 | 0.94 | MAT2A (0.43) | MAT2AACVR1ELANEMAPTTSHR | |
| SCHEMBL7751033 | 0.92 | MAT2A (0.42) | MAT2AACVR1ELANETSHRPOLB | |
| SCHEMBL4254009 | 0.92 | MAT2A (0.42) | MAT2AACVR1ELANETSHRPOLB | |
| SCHEMBL7745115 | 0.91 | MAT2A (0.42) | MAT2AACVR1ELANETSHRPOLB | |
| SCHEMBL4077829 | 0.91 | MAT2A (0.43) | MAT2AACVR1ELANETSHRPOLB | |
| SCHEMBL7745809 | 0.91 | MAT2A (0.43) | MAT2AACVR1ELANETSHRPOLB | |
| SCHEMBL7752199 | 0.90 | ELANE (0.42) | MAT2AACVR1ELANEMAPTTSHR | |
| SCHEMBL4083507 | 0.90 | MAT2A (0.43) | MAT2AACVR1ELANEMAPTTSHR | |
| SCHEMBL7749860 | 0.89 | ACVR1 (0.43) | MAT2AACVR1ELANEMAPTTSHR | |
| SCHEMBL4078860 | 0.89 | ACVR1 (0.43) | MAT2AACVR1ELANEMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6680324-B2 | 4-AMINO-6-PHENYL-PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2004-01-20 | — | — | US | disclosed |