SCHEMBL7751081

SCHEMBL7751081

CCCCC[Si]1(c2ccccc2)CCC(c2cc(F)c(O)c(F)c2)CC1

nearest known ligand 0.32

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DRD5 P21918 11/20 0.32
HTR1A P08908 7/20 0.32
DRD1 P21728 7/20 0.32
DRD4 P21917 7/20 0.32
DRD3 P35462 7/20 0.32
SLC18A3 Q16572 1/20 0.32
DRD2 P14416 7/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
OPRM1 P35372 1/20 0.31
OPRD1 P41143 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8580161 0.93
SCHEMBL8579053 0.93
SCHEMBL8579051 0.93
SCHEMBL7759616 0.91 BCHE (0.32) ALDH1A1LMNAGAAMAPT
SCHEMBL8579023 0.90 RARB (0.32) DRD5SLC18A3ALDH1A1LMNAGAA
SCHEMBL8578901 0.89 RARB (0.34) DRD5HTR1ADRD1DRD4DRD3
SCHEMBL8580118 0.89 RARB (0.34) DRD5HTR1ADRD1DRD4DRD3
SCHEMBL9010499 0.88 DRD5 (0.33) DRD5HTR1ADRD1DRD4DRD3
SCHEMBL7755532 0.87 PTPN1 (0.34) SLC18A3
SCHEMBL7755534 0.87 PTPN1 (0.34) SLC18A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0708107-B1 Novel silacyclohexane compounds, a liquid crystal composition comprising the same and a liquid crystal device comprising the composition SHINETSU CHEMICAL CO (JP) 2001-02-28 EP disclosed
US-5624601-A Silacyclohexane compounds, a liquid crystal composition comprising the same and a liquid crystal device comprising the composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-04-29 US disclosed
EP-0708107-A1 Novel silacyclohexane compounds, a liquid crystal composition comprising the same and a liquid crystal device comprising the composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-04-24 EP disclosed