Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 14/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 14/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 14/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.60 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924472 | 0.95 | HDAC1 (0.63) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL3915921 | 0.93 | HDAC1 (0.66) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL3914086 | 0.93 | HDAC1 (0.66) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL9157833 | 0.89 | MAPT (0.60) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL23543523 | 0.85 | HDAC1 (0.55) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL10571283 | 0.84 | CYP3A4 (0.51) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL5368440 | 0.83 | HDAC3 (0.62) | HDAC1HDAC6HDAC3HDAC2KDM4E | |
| SCHEMBL11923469 | 0.83 | HDAC3 (0.62) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL6296181 | 0.83 | HDAC4 (0.75) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL517309 | 0.83 | HDAC4 (0.81) | HDAC4HDAC1HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068185-A1 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | Acadia Pharmaceuticals Inc. (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999050247-A1 | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS | ACADIA PHARMACEUTICALS, INC. (US) | 1999-10-07 | — | — | WO | disclosed |