Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24590187 | 0.92 | HDAC3 (0.58) | HDAC3HDAC1HDAC2HDAC6KMT2A | |
| SCHEMBL22667768 | 0.84 | TP53 (0.55) | HDAC3HDAC1HDAC2HDAC6ALDH1A1 | |
| SCHEMBL7751695 | 0.83 | HDAC4 (0.60) | HDAC3HDAC1HDAC2HDAC6MAPT | |
| SCHEMBL18425276 | 0.81 | HDAC3 (0.68) | HDAC3HDAC1HDAC2HDAC6KMT2A | |
| SCHEMBL11923469 | 0.81 | HDAC3 (0.62) | HDAC3HDAC1HDAC2HDAC6ALDH1A1 | |
| SCHEMBL27561607 | 0.80 | HDAC3 (0.71) | HDAC3HDAC1HDAC2HDAC6KMT2A | |
| SCHEMBL20922087 | 0.80 | HDAC3 (0.71) | HDAC3HDAC1HDAC2HDAC6KMT2A | |
| SCHEMBL5328815 | 0.80 | HPGD (0.65) | HDAC3HDAC1HDAC2HDAC6KMT2A | |
| SCHEMBL3924472 | 0.79 | HDAC1 (0.63) | HDAC3HDAC1HDAC2HDAC6MAPT | |
| SCHEMBL4132292 | 0.79 | HDAC3 (0.73) | HDAC3HDAC1HDAC2HDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |