Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749143 | 0.94 | MEN1 (0.36) | MEN1KMT2AKDM4CKCNA5SCN5A | |
| SCHEMBL8207606 | 0.93 | MEN1 (0.39) | MEN1KMT2AKDM4CKCNA5SCN5A | |
| SCHEMBL7958095 | 0.88 | MEN1 (0.44) | MEN1KMT2AKDM4CKCNA5SCN5A | |
| SCHEMBL8124689 | 0.88 | MEN1 (0.43) | MEN1KMT2AKDM4CKCNA5SCN5A | |
| SCHEMBL7426709 | 0.88 | MEN1 (0.43) | MEN1KMT2AKDM4CKCNA5SCN5A | |
| SCHEMBL4678659 | 0.86 | MEN1 (0.40) | MEN1KMT2AKDM4CEPHA2SLC6A3 | |
| SCHEMBL7956480 | 0.84 | MEN1 (0.39) | MEN1KMT2AKDM4CEPHA2SLC6A3 | |
| SCHEMBL6543753 | 0.84 | MEN1 (0.38) | MEN1KMT2AEPHA2SLC6A3 | |
| SCHEMBL8484373 | 0.84 | MEN1 (0.38) | MEN1KMT2AKDM4CEPHA2SLC6A3 | |
| SCHEMBL7765828 | 0.84 | MEN1 (0.41) | MEN1KMT2AKDM4CKCNA5SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242637-B1 | USED IN TREATMENT INVOLVING THE TACHYKININ SYSTEM, SUCH AS PAIN, ALLERGY AND INFLAMMATION, CIRCULATORY, GASTROINTESTINAL, NEUROLOGICAL, AND NEUROPSYCHIATRIC DISORDERS | SANOFI-SYNTHELABO (FR) | 2001-06-05 | — | — | US | disclosed |
| US-6011154-A | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present | SANOFI (FR) | 2000-01-04 | — | — | US | disclosed |
| US-5977359-A | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present | SANOFI (FR) | 1999-11-02 | — | — | US | disclosed |
| US-5869663-A | INTERMEDIATES FOR NEUROKININ RECEPTOR ANTAGONISTS | SANOFI (FR) | 1999-02-09 | — | — | US | disclosed |
| US-5780466-A | DISORDERS ASSOCIATED WITH EXCESS TACHYKININS AND ALL NEUROKININ-DEPENDENT DISORDERS; ANALGESICS; RESPIRATORY, GASTROINTESTINAL, UROGENTIAL, IMMUNE, CARDIOVASCULAR AND CNS DISORDERS | SANOFI (FR) | 1998-07-14 | — | — | US | disclosed |
| US-5641777-A | NEUROKININ RECEPTOR ANTAGONIST | SANOFI (FR) | 1997-06-24 | — | — | US | disclosed |