SCHEMBL7752229

SCHEMBL7752229

[CH2]CC(CCCc1ccccc1)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 3/20 0.47
CYP19A1 P11511 2/20 0.43
SIGMAR1 Q99720 3/20 0.42
MAOA P21397 1/20 0.41
HTR3A P46098 1/20 0.40
CHRM2 P08172 1/20 0.40
HTR1A P08908 1/20 0.40
ADRA2A P08913 1/20 0.40
CHRM1 P11229 1/20 0.40
DRD1 P21728 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
ADRA1A P35348 1/20 0.40
OPRM1 P35372 1/20 0.40
DRD3 P35462 1/20 0.40
SLC6A3 Q01959 1/20 0.40
CNR1 P21554 1/20 0.40
ACP3 P15309 1/20 0.40
MAOB P27338 1/20 0.39
HTR2A P28223 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8197544 0.94 CYP19A1 (0.48) KCNH2CYP19A1SIGMAR1MAOAMAOB
SCHEMBL205557 0.88 CYP19A1 (0.49) KCNH2CYP19A1SIGMAR1SLC6A2SLC6A4
SCHEMBL155801 0.87 KCNH2 (0.46) KCNH2CYP19A1SIGMAR1MAOAHTR3A
SCHEMBL8091508 0.84 CYP2A6 (0.49)
SCHEMBL7376590 0.84 ALDH1A1 (0.54) SIGMAR1OPRM1
SCHEMBL6159713 0.84 CFTR (0.45) SLC6A2SLC6A4SLC6A3
SCHEMBL6283212 0.81 KCNH2 (0.48) KCNH2CYP19A1SIGMAR1CHRM2HTR1A
SCHEMBL8014868 0.81 KCNH2 (0.47) KCNH2CYP19A1SIGMAR1MAOACHRM2
SCHEMBL6796313 0.79 CYP19A1 (0.45) KCNH2CYP19A1SIGMAR1SLC6A2SLC6A4
SCHEMBL9480601 0.79 KCNH2 (0.46) KCNH2CYP19A1SIGMAR1MAOAADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4217454-A Process for stereoselectively reducing indole derivatives ENDO LABORATORIES, INC. (US) 1980-08-12 US claimed
WO-2001042245-A1 NEUROTROPHIC BICYCLIC DIAMIDES BRISTOL-MYERS SQUIBB COMPANY (US) 2001-06-14 WO disclosed
US-6133276-A A LIGAND INHIBITOR OF A CRF/CRF-BINDING PROTEIN COMPLEX TO EFFECT INCREASED LEVELS OF CRF; 2,4-DIOXO- OR 2-THIOCARBONYL-4-OXO-5-(HYDROCARBYL(THIO)CARBONYLAMINOMETHYL)-6-HYDROXY-HEXA-HEXAHYDROPYRIMIDINES; ALZHEIMER'S, OBESITY; LOW SIDE EFFECTS NEUROCRINE BIOSCIENCES, INC. (US) 2000-10-17 US disclosed
US-5959109-A A LIGAND INHIBITOR CAUSES RELASES OF CORTICOTROPIN-RELEASING FACTOR FROM THE CORTICOTROPIN/CORTICOTROPIN-BINDING PROTEIN COMPLEX, PROVIDES IMPROVEMENT IN LEARNING AND MEMORY NEUROCRINE BIOSCIENCES, INC. (US) 1999-09-28 US disclosed
US-5591714-A TREATING VANCOMYCIN RESISTANT ENTEROCOCCUS INFECTIONS WITH GLYCOPEPTIDE ANTIBIOTIC ELI LILLY AND COMPANY (US) 1997-01-07 US disclosed
US-5145869-A Treatment of irritable bowel syndrome, dyskinesia, pancreatist; hormone inhibitors KISSEI PHARMACEUTICAL CO., LTD. (JP) 1992-09-08 US disclosed
US-4217454-A Process for stereoselectively reducing indole derivatives ENDO LABORATORIES, INC. (US) 1980-08-12 US disclosed