Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL8521651 | 0.93 | MEN1 (0.48) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL456806 | 0.83 | — | — | |
| Morpholine SCHEMBL20549040 | 0.83 | TSHR (0.56) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL28825908 | 0.83 | KDM4E (0.48) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL11338140 | 0.80 | MEN1 (0.65) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Piperazine SCHEMBL4019578 | 0.80 | TP53 (0.57) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Dioxane SCHEMBL5252714 | 0.80 | TP53 (0.57) | MEN1KMT2AGAATP53HTT | |
| Morpholine SCHEMBL25265618 | 0.80 | MEN1 (0.44) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL1579459 | 0.78 | — | — | |
| Morpholine SCHEMBL1121824 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102639480-A | Method for producing alizarin derivative compound, novel alizarin derivative compound, surface modification method, photoelectric conversion film, photoelectric conversion element, and electrophotographic photoreceptor | FUJIFILM CORP | 2012-08-15 | — | — | CN | disclosed |
| WO-2001051505-A1 | Nα-2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACID FLUORIDES AND PROCESS FOR THE PREPARATION THEREOF | HYUNDAI PHARMACEUTICAL IND. CO., LTD. (KR) | 2001-07-19 | — | — | WO | disclosed |
| EP-0765307-B1 | N ALPHA-2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACIDS | HYUNDAI PHARM IND CO LTD (KR) | 1999-10-20 | — | — | EP | disclosed |
| EP-0765307-A1 | N ALPHA-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS | Hyundai Pharm. Ind. Co., Ltd. (KR) | 1997-04-02 | — | — | EP | disclosed |
| US-5616788-A | FOR SOLID PHASE PEPTIDE SYNTHESIS | HYUNDAI PHARM. IND. CO., LTD. (KR) | 1997-04-01 | — | — | US | disclosed |
| WO-1996025394-A1 | Nα-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS | HYUNDAI PHARM. IND. CO., LTD. (KR) | 1996-08-22 | — | — | WO | disclosed |