SCHEMBL7756352

SCHEMBL7756352

C=CCc1ccc(C(=O)O)cc1C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARG P13631 11/20 0.58
RARB P10826 10/20 0.58
RARA P10276 10/20 0.54
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
KDM4E B2RXH2 1/20 0.49
ALDH1A1 P00352 1/20 0.49
TP53 P04637 1/20 0.49
CYP3A4 P08684 1/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
ALOX15 P16050 1/20 0.49
ALOX12 P18054 1/20 0.49
MAPK1 P28482 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
HSD17B10 Q99714 1/20 0.49
NR1I2 O75469 1/20 0.46
LMNA P02545 1/20 0.46
PGR P06401 1/20 0.46
HSPD1 P10809 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9364275 0.90 RARG (0.52) RARGRARBRARAMEN1KMT2A
SCHEMBL8766179 0.88 RARG (0.78) RARGRARBRARAMEN1KMT2A
SCHEMBL5888178 0.86 RARB (0.45) RARGRARBRARAMEN1KMT2A
SCHEMBL9125756 0.85 RARG (0.62) RARGRARBRARAMEN1KMT2A
SCHEMBL9011468 0.81 MEN1 (0.67) RARGRARBRARAMEN1KMT2A
SCHEMBL9127643 0.81 RARG (0.52) RARGRARBRARAMEN1KMT2A
SCHEMBL7753714 0.80 RARG (0.79) RARGRARBRARAMEN1KMT2A
SCHEMBL9321437 0.80 RARA (0.54) RARGRARBRARAMEN1KMT2A
SCHEMBL9129359 0.79 RARG (0.64) RARGRARBRARAMEN1KMT2A
SCHEMBL7757395 0.77 RARA (0.75) RARGRARBRARAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0850909-B1 Stilbene compounds with adamantyl group, compositions containing the same and uses CT INTERNAT DE (FR) 2001-03-21 EP disclosed
EP-0850909-A1 Stilbene compounds with adamantyl group, compositions containing the same and uses CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 1998-07-01 EP disclosed