SCHEMBL7756512

SCHEMBL7756512

CCCCC[SiH]1CCC(C2CCC(c3cc(F)c(-c4ccc(OC(F)(F)F)cc4)c(F)c3)CC2)CC1

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.34
KDM1A O60341 1/20 0.31
RCOR1 Q9UKL0 1/20 0.31
EPHX2 P34913 1/20 0.31
FFAR4 Q5NUL3 2/20 0.31
LIPE Q05469 1/20 0.31
FFAR1 O14842 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
HDAC3 O15379 1/20 0.30
HDAC1 Q13547 1/20 0.30
HDAC2 Q92769 1/20 0.30
BTK Q06187 1/20 0.30
PDE2A O00408 1/20 0.30
GRIN2B Q13224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7756504 1.00 SCN9A (0.34) SCN9AKDM1ARCOR1EPHX2FFAR4
SCHEMBL8537683 0.94 KDM1A (0.32) SCN9AKDM1ARCOR1FFAR4L3MBTL1
SCHEMBL8537682 0.94 KDM1A (0.32) SCN9AKDM1ARCOR1FFAR4L3MBTL1
SCHEMBL7755773 0.94 KDM1A (0.32) SCN9AKDM1ARCOR1FFAR4L3MBTL1
SCHEMBL8393943 0.94 SCN9A (0.36) SCN9AKDM1ARCOR1EPHX2FFAR4
SCHEMBL8393940 0.94 SCN9A (0.36) SCN9AKDM1ARCOR1EPHX2FFAR4
SCHEMBL8771255 0.91 SCN9A (0.35) SCN9AKDM1ARCOR1EPHX2FFAR4
SCHEMBL8771250 0.91 SCN9A (0.35) SCN9AKDM1ARCOR1EPHX2FFAR4
SCHEMBL8017659 0.89 GRM2 (0.36) SCN9AKDM1ARCOR1EPHX2FFAR4
SCHEMBL8017658 0.89 GRM2 (0.36) SCN9AKDM1ARCOR1EPHX2FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0718387-B1 A liquid crystal composition and a liquid crystal display element which contains it SHINETSU CHEMICAL CO (JP) 2001-03-14 EP disclosed
EP-0670322-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 2000-01-19 EP disclosed
US-5762826-A Liquid crystal composition and a liquid crystal display element which contains it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-06-09 US disclosed
US-5582764-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-12-10 US disclosed
EP-0718387-A1 A liquid crystal composition and a liquid crystal display element which contains it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-26 EP disclosed
EP-0670322-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-09-06 EP disclosed