Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 20/20 | 0.71 |
| ▸ | RXRB | P28702 | 10/20 | 0.71 |
| ▸ | RXRG | P48443 | 10/20 | 0.71 |
| ▸ | RARB | P10826 | 5/20 | 0.71 |
| ▸ | RARG | P13631 | 4/20 | 0.71 |
| ▸ | RARA | P10276 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ESR1 | P03372 | 1/20 | 0.71 |
| ▸ | PGR | P06401 | 1/20 | 0.71 |
| ▸ | HTR1A | P08908 | 1/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | DRD1 | P21728 | 1/20 | 0.71 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7889468 | 0.86 | RXRA (0.60) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6901726 | 0.86 | RXRA (0.69) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8695591 | 0.85 | RXRA (0.70) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL16926946 | 0.85 | RXRA (0.78) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8331490 | 0.85 | RXRA (0.70) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL16926725 | 0.84 | RXRA (0.67) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8333900 | 0.84 | RXRA (0.70) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7761577 | 0.83 | RXRA (0.70) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL4450645 | 0.83 | RXRA (0.80) | RXRARXRBRXRGRARBRARG | |
| Bexarotene SCHEMBL5322954 | 0.83 | RXRA (1.00) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915823-B1 | BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES | CT INTERNAT DE (FR) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000026172-A1 | TRIENOIC RETINOID COMPOUNDS AS RETINOIC ACID RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2000-05-11 | — | — | WO | disclosed |
| US-5962731-A | MODIFY LIPID METABOLISM; SKIN DISORDERS,; AUTOIMMUNE DISEASES; FATTY ACID METABOLISM; ANTITUMOR AGENTS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-10-05 | — | — | US | disclosed |
| EP-0915823-A1 | BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1999-05-19 | — | — | EP | disclosed |
| US-5837725-A | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors | SRI INTERNATIONAL (US) | 1998-11-17 | — | — | US | disclosed |
| US-5780676-A | BICYCLIC BENZYL, PYRIDINYL, THIOPHENE, FURANYL, PYRROLE, AND POLYENOIC ACID DERIVATIVES | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1998022423-A1 | BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1998-05-28 | — | — | WO | disclosed |