SCHEMBL7756578

SCHEMBL7756578

CC(c1cccc(/C=C/C(=O)O)c1)c1ccc2c(c1)C(C)(C)CCC2(C)C

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RXRA P19793 7/20 0.58
RXRB P28702 1/20 0.58
CYP26A1 O43174 2/20 0.55
CYP26B1 Q9NR63 1/20 0.51
CYP3A4 P08684 1/20 0.50
RARA P10276 9/20 0.48
RARB P10826 7/20 0.48
RARG P13631 7/20 0.48
KDM4E B2RXH2 1/20 0.43
MAPK1 P28482 1/20 0.43
NR4A2 P43354 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7756582 1.00 RXRA (0.58) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7759633 0.88 CYP26A1 (0.56) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7761238 0.85 RXRA (0.58) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7760222 0.85 RXRA (0.58) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7761308 0.85 RXRA (0.49) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7761301 0.85 RXRA (0.49) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7760182 0.83 RXRA (0.51) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7760185 0.83 RXRA (0.51) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7756633 0.82 RXRA (0.50) RXRARXRBCYP26A1CYP26B1CYP3A4
SCHEMBL7761643 0.82 RXRA (0.50) RXRARXRBCYP26A1CYP26B1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US claimed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP claimed
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US disclosed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP disclosed