SCHEMBL7756592

SCHEMBL7756592

CCOC(=O)C=Cc1ccccc1C(C)c1cc2c(cc1C)C(C)(C)CCC2(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 7/20 0.47
HNF4A P41235 2/20 0.39
BACE1 P56817 2/20 0.38
RARG P13631 2/20 0.37
RARA P10276 1/20 0.37
RARB P10826 1/20 0.37
ESR1 P03372 2/20 0.37
CYP3A4 P08684 2/20 0.37
CCNC P24863 1/20 0.37
CDK8 P49336 1/20 0.37
RXRG P48443 4/20 0.36
RXRB P28702 2/20 0.36
ALOX5 P09917 1/20 0.36
TTR P02766 1/20 0.36
DPP4 P27487 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7756587 1.00 RXRA (0.47) RXRAHNF4ABACE1RARGRARA
SCHEMBL7761260 0.89 RXRA (0.46) RXRAHNF4ABACE1RARGRARA
SCHEMBL7759730 0.89 RXRA (0.46) RXRAHNF4ABACE1RARGRARA
SCHEMBL7759787 0.86 RXRA (0.54) RXRAHNF4ARARGRARARARB
SCHEMBL7759790 0.86 RXRA (0.54) RXRAHNF4ARARGRARARARB
SCHEMBL7761259 0.82 RXRA (0.50) RXRAHNF4ABACE1CYP3A4ALOX5
SCHEMBL7762902 0.82 RXRA (0.50) RXRAHNF4ABACE1CYP3A4ALOX5
SCHEMBL6874278 0.81 RXRA (0.47) RXRABACE1RARGRARARARB
SCHEMBL7761217 0.80 RXRA (0.46) RXRAHNF4ARARGRARARARB
SCHEMBL7761213 0.80 RXRA (0.46) RXRAHNF4ARARGRARARARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US claimed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP claimed
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US disclosed