Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 1/20 | 0.58 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850554 | 0.84 | TCF4 (0.66) | TCF4CTNNB1POLBMAPTLMNA | |
| SCHEMBL1850553 | 0.84 | TCF4 (0.66) | TCF4CTNNB1POLBMAPTLMNA | |
| SCHEMBL3814590 | 0.77 | NPC1 (0.82) | ABCG2POLBMAPTLMNAHPGD | |
| SCHEMBL1848235 | 0.76 | TCF4 (0.62) | TCF4CTNNB1POLBMAPTLMNA | |
| SCHEMBL2159392 | 0.76 | TCF4 (0.62) | TCF4CTNNB1POLBMAPTLMNA | |
| SCHEMBL2846423 | 0.75 | SRD5A2 (0.50) | TCF4CTNNB1POLBMAPTHPGD | |
| SCHEMBL2846425 | 0.75 | SRD5A2 (0.50) | TCF4CTNNB1POLBMAPTHPGD | |
| SCHEMBL1849660 | 0.75 | TCF4 (0.69) | TCF4CTNNB1POLBMAPTLMNA | |
| SCHEMBL1849661 | 0.75 | TCF4 (0.69) | TCF4CTNNB1POLBMAPTLMNA | |
| SCHEMBL22320751 | 0.75 | TCF4 (1.00) | TCF4CTNNB1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728755-B1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | EP | disclosed |
| US-RE37078-E1 | Thiophene compounds | ADIR ET COMPAGNIE (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0728755-A1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-08-28 | — | — | EP | disclosed |