Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP7 | O15540 | 4/20 | 0.73 |
| ▸ | FABP5 | Q01469 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7757006 | 1.00 | FABP7 (0.73) | FABP7FABP5ALDH1A1TDP1MAPK1 | |
| SCHEMBL12114007 | 1.00 | FABP7 (0.73) | FABP7FABP5ALDH1A1TDP1MAPK1 | |
| SCHEMBL31509821 | 1.00 | FABP7 (0.73) | FABP7FABP5ALDH1A1TDP1MAPK1 | |
| SCHEMBL7756954 | 1.00 | FABP7 (0.73) | FABP7FABP5ALDH1A1TDP1MAPK1 | |
| SCHEMBL13432587 | 1.00 | FABP7 (0.73) | FABP7FABP5ALDH1A1TDP1MAPK1 | |
| SCHEMBL7757018 | 1.00 | FABP7 (0.73) | FABP7FABP5ALDH1A1TDP1MAPK1 | |
| SCHEMBL31509827 | 0.87 | FABP7 (0.58) | FABP7FABP5ALDH1A1TDP1MAPK1 | |
| SCHEMBL8826317 | 0.87 | FABP7 (0.59) | FABP7FABP5SMN1; SMN2 | |
| SCHEMBL8826314 | 0.87 | FABP7 (0.59) | FABP7FABP5SMN1; SMN2 | |
| SCHEMBL12114095 | 0.86 | FABP7 (0.65) | FABP7FABP5ALDH1A1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821665-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1090908-A2 | Cyclobutane derivatives as inhibitors of protein farnesyltransferase | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5831115-A | CYCLOBUTANECARBOXAMIDES | ABBOTT LABORATORIES (US) | 1998-11-03 | — | — | US | disclosed |
| US-5783593-A | FUNGICIDE; ANTICHOLESTEROL AGENT | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |