Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 13/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.72 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.72 |
| ▸ | DRD3 | P35462 | 5/20 | 0.60 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.60 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.60 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | DRD4 | P21917 | 4/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3895655 | 0.91 | OPRM1 (0.61) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL10736433 | 0.84 | OPRL1 (0.75) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL5248548 | 0.83 | OPRL1 (0.73) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL7847623 | 0.82 | OPRL1 (1.00) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL5248493 | 0.81 | OPRL1 (0.71) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL5925337 | 0.80 | OPRL1 (0.69) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL5925355 | 0.80 | OPRL1 (0.69) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL6571230 | 0.80 | OPRL1 (0.69) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL7757055 | 0.80 | OPRL1 (0.56) | OPRL1OPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL7848856 | 0.80 | OPRL1 (0.76) | OPRL1OPRM1OPRD1OPRK1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277991-B1 | FOR TREATMENT OF MIGRAINE, NON-INSULIN DEPENDENT DIABETES MELLITUS, SEPSIS, INFLAMMATION, INCONTINENCE, VASOMOTOR DISTURBANCES SUCH AS HOT FLUSHES OR HOT FLASHES | NOVO NORDISK A/S (DK) | 2001-08-21 | — | — | US | disclosed |
| EP-1080091-A1 | NOVEL 1,3,8-TRIAZASPIRO[4.5]DECANONES WITH HIGH AFFINITY FOR OPIOID RECEPTOR SUBTYPES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059997-A1 | NOVEL 1,3,8-TRIAZASPIRO[4.5]DECANONES WITH HIGH AFFINITY FOR OPIOID RECEPTOR SUBTYPES | NOVO NORDISK A/S (DK) | 1999-11-25 | — | — | WO | disclosed |