SCHEMBL7757326

SCHEMBL7757326

O=C(CCc1cccnc1)NCCCCC1CCN(Cc2ccccc2)CC1.O=C(CCc1cccnc1)NCCCCC1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.53
HDAC4 P56524 1/20 0.53
HDAC1 Q13547 1/20 0.53
HDAC7 Q8WUI4 1/20 0.53
HDAC2 Q92769 1/20 0.53
HDAC10 Q969S8 1/20 0.53
HDAC11 Q96DB2 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
HDAC9 Q9UKV0 1/20 0.53
HDAC5 Q9UQL6 1/20 0.53
ALDH1A1 P00352 3/20 0.50
KDM4E B2RXH2 1/20 0.50
ACHE P22303 3/20 0.47
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
DRD4 P21917 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
BCHE P06276 2/20 0.46
CHRM4 P08173 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3080350 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL83006 0.87 ACHE (0.57) ACHEMAOAMAOBBCHECHRM4
SCHEMBL6776977 0.82 HDAC3 (0.54) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL82572 0.81 ACHE (0.65) ACHEMAOAMAOBBCHECHRM4
SCHEMBL82281 0.80 NAMPT (0.51) ALDH1A1NAMPTKMT2A
SCHEMBL5399704 0.80 NAMPT (0.55) DRD4NAMPT
SCHEMBL5557298 0.79 HDAC3 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3077271 0.77 NAMPT (0.64) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3077273 0.77 NAMPT (0.64) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3079290 0.77 CHRM4 (0.47) ALDH1A1ACHEMAOAMAOBDRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1079832-A1 USE OF VITAMIN PP COMPOUNDS Klinge Pharma GmbH (DE) 2001-03-07 EP disclosed
WO-1999053920-A1 USE OF VITAMIN PP COMPOUNDS KLINGE PHARMA GMBH (DE) 1999-10-28 WO disclosed