Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.55 |
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9544551 | 0.94 | PPARA (0.59) | SIRT2SIRT1PPARAPPARGHDAC3 | |
| SCHEMBL9544644 | 0.94 | PPARA (0.59) | SIRT2SIRT1PPARAPPARGHDAC3 | |
| SCHEMBL9544528 | 0.94 | PPARA (0.59) | SIRT2SIRT1PPARAPPARGHDAC3 | |
| SCHEMBL7757498 | 0.92 | PPARA (0.56) | SIRT2SIRT1PPARAPPARGHDAC3 | |
| SCHEMBL7757493 | 0.91 | PPARA (0.53) | SIRT2SIRT1PPARAPPARGHDAC3 | |
| SCHEMBL9544195 | 0.89 | PPARA (0.61) | SIRT2SIRT1PPARAPPARGHDAC3 | |
| SCHEMBL7762822 | 0.84 | GMNN (0.39) | SIRT2SIRT1 | |
| SCHEMBL7757470 | 0.82 | HDAC3 (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7708741 | 0.82 | PPARA (0.53) | SIRT2SIRT1PPARAPPARGHDAC3 | |
| SCHEMBL5507111 | 0.82 | PPARA (0.53) | SIRT2SIRT1PPARAPPARGHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251882-B1 | TREATING LEUKEMIA, BREAST CANCER, PROSTATE CANCER, OR BRAIN TUMOR | PARKER HUGHES INSTITUTE | 2001-06-26 | — | — | US | claimed |
| EP-1091934-A2 | ALKYL KETONES AS POTENT ANTI-CANCER AGENTS | Parker Hughes Institute (US) | 2001-04-18 | — | — | EP | claimed |
| WO-2000000469-A2 | ALKYL KETONES AS POTENT ANTI-CANCER AGENTS | PARKER HUGHES INSTITUTE (US) | 2000-01-06 | — | — | WO | claimed |
| US-6251882-B1 | TREATING LEUKEMIA, BREAST CANCER, PROSTATE CANCER, OR BRAIN TUMOR | PARKER HUGHES INSTITUTE | 2001-06-26 | — | — | US | disclosed |
| EP-1091934-A2 | ALKYL KETONES AS POTENT ANTI-CANCER AGENTS | Parker Hughes Institute (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000469-A2 | ALKYL KETONES AS POTENT ANTI-CANCER AGENTS | PARKER HUGHES INSTITUTE (US) | 2000-01-06 | — | — | WO | disclosed |