Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5918845 | 0.85 | MEN1 (0.40) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL3931412 | 0.84 | MEN1 (0.39) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL3931417 | 0.84 | MEN1 (0.39) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| Iodide SCHEMBL1806983 | 0.84 | KDM4E (0.59) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL278447 | 0.83 | KDM4E (0.57) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL13098676 | 0.77 | MEN1 (0.38) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL3934283 | 0.73 | MEN1 (0.37) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL3934279 | 0.73 | MEN1 (0.37) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL10023161 | 0.72 | MAPT (0.41) | MEN1MAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL12302044 | 0.72 | MEN1 (0.33) | MEN1MAPTKMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714986-B1 | Method of detecting specific nucleic acid sequences | TOSOH CORP (JP) | 2001-03-14 | — | — | EP | disclosed |
| EP-0714986-A1 | Method of detecting specific nucleic acid sequences | Tosoh Corporation (JP) | 1996-06-05 | — | — | EP | disclosed |