Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.74 |
| ▸ | DAO | P14920 | 1/20 | 0.74 |
| ▸ | CES2 | O00748 | 3/20 | 0.61 |
| ▸ | CES1 | P23141 | 3/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL11532372 | 0.89 | TSHR (0.71) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL17822361 | 0.89 | TSHR (0.58) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL7164504 | 0.86 | TSHR (0.78) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL28921708 | 0.86 | TSHR (0.78) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL2178877 | 0.86 | TSHR (0.78) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL27672254 | 0.86 | TSHR (0.78) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL6869498 | 0.86 | TSHR (0.88) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL3044510 | 0.86 | TSHR (0.88) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL160564 | 0.86 | TSHR (1.00) | TSHRNAPRTDAOCES2CES1 | |
| Benzoic Acid SCHEMBL3966600 | 0.86 | TSHR (1.00) | TSHRNAPRTDAOCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001056385-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 2001-08-09 | — | — | WO | claimed |
| EP-0813510-A4 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 2000-07-26 | — | — | EP | claimed |
| EP-0813510-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA, Arthur M. (US) | 1997-12-29 | — | — | EP | claimed |
| WO-1996027572-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 1996-09-12 | — | — | WO | claimed |
| US-4435567-A | REACTING AN AMINE WITH AN N-CARBAMOYL BENZOIC ACID SULFIMIDE | CHINOIN GYOGYSZER ES VESGYESZETI TERMEKEK GYARA R. T. (HU) | 1984-03-06 | — | — | US | claimed |
| CN-108587994-A | A kind of engineering bacteria and its structure with cyclic imide hydrolase activity D- hydantoin enzymes, cultural method and application | 山西大学 | 2018-09-28 | — | — | CN | disclosed |
| CN-101310222-B | Photosensitive composition, photosensitive film, permanent pattern and method for forming the same | FUJI PHOTO FILM CO LTD | 2011-09-07 | — | — | CN | disclosed |
| CN-100548288-C | Memory fixation promoter | RES FOUNDATION ITSUU LAB R & R (JP) | 2009-10-14 | — | — | CN | disclosed |
| CN-101316584-A | Pharmaceutical for prevention and treatment of ophthalmic disease induced by increase in vasopermeability | HOKKAIDO (JP) | 2008-12-03 | — | — | CN | disclosed |
| CN-101310222-A | Photosensitive composition, photosensitive film, permanent pattern and method for forming the same | FUJIFILM CORP (JP) | 2008-11-19 | — | — | CN | disclosed |
| CN-1964709-A | Memory fixation promoter | RES FOUND ITSUU LAB (JP) | 2007-05-16 | — | — | CN | disclosed |
| US-6121195-A | STIMULATING CARBON FIXATION AND INCREASING THE GROWTH OF PLANTS BY ENHANCING THE AVAILABILITY OF C1-TETRAHYDROFOLATE IN THE LEAVES OF A PLANT | NONOMURA ARTHUR M (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0813510-A4 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5846908-A | Methods and compositions for enhancing plant growth with p-amino- or p-nitro-benzoic acids | NONOMURA ARTHUR M (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0813510-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA, Arthur M. (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1996027572-A1 | METHODS AND COMPOSITIONS FOR ENHANCING FORMYLTETRAHYDROPTEROYLPOLYGLUTAMATE IN PLANTS | NONOMURA ARTHUR M (US) | 1996-09-12 | — | — | WO | disclosed |
| US-4435567-A | REACTING AN AMINE WITH AN N-CARBAMOYL BENZOIC ACID SULFIMIDE | CHINOIN GYOGYSZER ES VESGYESZETI TERMEKEK GYARA R. T. (HU) | 1984-03-06 | — | — | US | disclosed |
| US-4435567-A | REACTING AN AMINE WITH AN N-CARBAMOYL BENZOIC ACID SULFIMIDE | CHINOIN GYOGYSZER ES VESGYESZETI TERMEKEK GYARA R. T. (HU) | 1984-03-06 | — | — | US | disclosed |