SCHEMBL7757922

SCHEMBL7757922

CCCCC(C)CC(c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)(C1CC(C)(C)N(C)C(C)(C)C1)C1CC(C)(C)N(C)C(C)(C)C1

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.33
NR5A2 O00482 1/20 0.32
NR5A1 Q13285 1/20 0.32
ALDH1A1 P00352 3/20 0.31
KDM4E B2RXH2 2/20 0.31
MAPT P10636 2/20 0.31
GAA P10253 1/20 0.30
XBP1 P17861 1/20 0.30
MAPK1 P28482 1/20 0.30
HTT P42858 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15525741 0.77 ALDH1A1 (0.34) ALDH1A1KDM4EMAPTGAAXBP1
SCHEMBL5795097 0.76 GAA (0.34) IDH1NR5A2NR5A1GAAXBP1
SCHEMBL25630 0.74 GAA (0.33) IDH1NR5A2NR5A1GAAXBP1
SCHEMBL689100 0.72 NR5A2 (0.38) IDH1NR5A2NR5A1ALDH1A1KDM4E
SCHEMBL11087592 0.72 NR5A2 (0.35) IDH1NR5A2NR5A1ALDH1A1KDM4E
SCHEMBL1345179 0.71 IDH1 (0.33) IDH1GAAXBP1HTTNPSR1
SCHEMBL224190 0.70 GAA (0.33) NR5A2NR5A1ALDH1A1GAAHTT
SCHEMBL7757931 0.70 ALDH1A1 (0.34) IDH1ALDH1A1KDM4EMAPTGAA
SCHEMBL25141789 0.69 HMGCR (0.39) IDH1ALDH1A1KDM4EMAPTGAA
SCHEMBL15726088 0.69 CACNA1A (0.35) IDH1NR5A2NR5A1GAAXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0667562-B1 Charge injection barrier for positive charging organic photoconductor HEWLETT PACKARD CO (US) 2001-03-21 EP claimed