SCHEMBL7759048

SCHEMBL7759048

Fc1ccc([C@H]2COCCN2Cc2nc[nH]n2)cc1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
CFB P00751 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
FKBP1A P62942 1/20 0.34
ALDH1A1 P00352 4/20 0.34
TDP1 Q9NUW8 1/20 0.34
GSK3B P49841 1/20 0.33
TACR1 P25103 3/20 0.33
KMT2A Q03164 3/20 0.32
MEN1 O00255 2/20 0.32
LMNA P02545 2/20 0.32
KDM4E B2RXH2 2/20 0.31
MAPT P10636 2/20 0.31
MAOB P27338 1/20 0.31
LTA4H P09960 1/20 0.31
TSHR P16473 1/20 0.31
RORC P51449 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6559883 1.00 HDAC1 (0.37) HDAC1HDAC8HDAC6CFBL3MBTL1
SCHEMBL23443025 0.77 TACR1 (0.49) HDAC1HDAC8HDAC6CFBTACR1
SCHEMBL19908470 0.77 TACR1 (0.49) HDAC1HDAC8HDAC6CFBTACR1
SCHEMBL28091456 0.76 RORC (0.48) L3MBTL1MAOBLTA4HRORC
SCHEMBL20623694 0.74 AKT1 (0.36) HDAC1HDAC8HDAC6CFBL3MBTL1
SCHEMBL9044444 0.71 CFB (0.35) HDAC1HDAC8HDAC6CFBALDH1A1
SCHEMBL7759041 0.71 CNR2 (0.49) KMT2AMEN1
SCHEMBL6559879 0.71 CNR2 (0.49) KMT2AMEN1
SCHEMBL18482369 0.69 CFB (0.35) HDAC1HDAC8HDAC6CFBTACR1
SCHEMBL27367885 0.67 ATR (0.40) HDAC1HDAC8HDAC6KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1119358-A1 USE OF AN NK-1 RECEPTOR ANTAGONIST FOR TREATING COGNITIVE DISORDERS MERCK SHARP & DOHME LTD. (GB) 2001-08-01 EP disclosed
EP-1087771-A1 USE OF A NK-1 RECEPTOR ANTAGONIST FOR TREATING BIPOLAR DISORDERS MERCK SHARP & DOHME LTD. (GB) 2001-04-04 EP disclosed
EP-1085875-A1 USE OF A NK-1 RECEPTOR ANTAGONIST FOR TREATING PSYCHIATRIC DISORDERS MERCK SHARP & DOHME LTD. (GB) 2001-03-28 EP disclosed
WO-1999064009-A1 USE OF AN NK-1 RECEPTOR ANTAGONIST FOR TREATING COGNITIVE DISORDERS MERCK SHARP & DOHME LIMITED (GB) 1999-12-16 WO disclosed
WO-1999064010-A1 USE OF A NK-1 RECEPTOR ANTAGONIST FOR TREATING PSYCHIATRIC DISORDERS MERCK SHARP & DOHME LIMITED (GB) 1999-12-16 WO disclosed
WO-1999064007-A1 USE OF A NK-1 RECEPTOR ANTAGONIST FOR TREATING BIPOLAR DISORDERS MERCK SHARP & DOHME LIMITED (GB) 1999-12-16 WO disclosed