⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14777112 | 0.78 | — | — | |
| SCHEMBL3618771 | 0.75 | — | — | |
| SCHEMBL7010827 | 0.73 | CA1 (0.31) | — | |
| SCHEMBL17595079 | 0.70 | — | — | |
| SCHEMBL2677181 | 0.70 | — | — | |
| SCHEMBL11651861 | 0.70 | — | — | |
| SCHEMBL28459258 | 0.66 | — | — | |
| SCHEMBL9639223 | 0.64 | — | — | |
| SCHEMBL27653258 | 0.63 | TSHR (0.37) | — | |
| SCHEMBL7631120 | 0.63 | MAPT (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3248594-A1 | TABLET FOR MULTIPLE ORAL APPLICATIONS | ratiopharm GmbH (DE) | 2017-11-29 | — | — | EP | disclosed |
| US-9301959-B2 | Orally dispersible tablet containing compacted sildenafil base | RATIOPHARM GMBH (DE) | 2016-04-05 | — | — | US | disclosed |
| EP-2515852-B1 | FUSION TABLET CONTAINING COMPACTED SILDENAFIL BASE | RATIOPHARM GMBH (DE) | 2016-03-02 | — | — | EP | disclosed |
| US-8933081-B2 | Melting tablet containing a sildenafil salt | RATIOPHARM GMBH (DE) | 2015-01-13 | — | — | US | disclosed |
| US-20140343072-A1 | ORALLY DISPERSIBLE TABLET CONTAINING COMPACTED SILDENAFIL BASE | RATIOPHARM GMBH (DE) | 2014-11-20 | — | — | US | disclosed |
| US-8808739-B2 | Orodispersible tablet containing compacted sildenafil base | RATIOPHARM GMBH (DE) | 2014-08-19 | — | — | US | disclosed |
| EP-2416755-B1 | MELTING TABLET CONTAINING A SILDENAFIL SALT | RATIOPHARM GMBH (DE) | 2013-03-27 | — | — | EP | disclosed |
| US-20120295916-A1 | ORODISPERSIBLE TABLET CONTAINING COMPACTED SILDENAFIL BASE | RATIOPHARM GMBH (DE) | 2012-11-22 | — | — | US | disclosed |
| US-20120071488-A1 | MELTING TABLET CONTAINING A SILDENAFIL SALT | RATIOPHARM GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| EP-2338474-A1 | Fusion tablet containing compacted sildenafil base | Ratiopharm GmbH (DE) | 2011-06-29 | — | — | EP | disclosed |