SCHEMBL7759686

SCHEMBL7759686

Cc1cc2c(cc1C(C)c1cccc(C=CC=O)c1)C(C)(C)CCC2(C)C

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RXRA P19793 11/20 0.51
CCNB2 O95067 3/20 0.37
CDK1 P06493 3/20 0.37
CDK4 P11802 3/20 0.37
CCNB1 P14635 3/20 0.37
CCND1 P24385 3/20 0.37
CCNB3 Q8WWL7 3/20 0.37
HNF4A P41235 3/20 0.36
RARG P13631 7/20 0.36
RARB P10826 6/20 0.36
RARA P10276 5/20 0.36
RXRB P28702 4/20 0.35
RXRG P48443 3/20 0.33
CYP26A1 O43174 1/20 0.33
TRPA1 O75762 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
ALOX5 P09917 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7756706 1.00 RXRA (0.51) RXRACCNB2CDK1CDK4CCNB1
SCHEMBL7760182 0.84 RXRA (0.51) RXRACCNB2CDK1CDK4CCNB1
SCHEMBL7760185 0.84 RXRA (0.51) RXRACCNB2CDK1CDK4CCNB1
SCHEMBL7760222 0.84 RXRA (0.58) RXRAHNF4ARARGRARBRARA
SCHEMBL7761238 0.84 RXRA (0.58) RXRAHNF4ARARGRARBRARA
SCHEMBL7759729 0.83 RXRA (0.50) RXRAHNF4ARARGRARBRARA
SCHEMBL7760240 0.83 RXRA (0.50) RXRAHNF4ARARGRARBRARA
SCHEMBL7762902 0.80 RXRA (0.50) RXRAHNF4AALDH1A1LMNAALOX5
SCHEMBL7761259 0.80 RXRA (0.50) RXRAHNF4AALDH1A1LMNAALOX5
SCHEMBL7760435 0.79 RXRA (0.47) RXRACCNB2CDK1CDK4CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US claimed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP claimed
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US disclosed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP disclosed
EP-0915823-A1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) 1999-05-19 EP disclosed
WO-1998022423-A1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 1998-05-28 WO disclosed