Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.33 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7759723 | 1.00 | KMT2A (0.53) | KMT2AKIF11RXRARXRBRXRG | |
| SCHEMBL7756420 | 0.91 | KMT2A (0.60) | KMT2AKIF11MAPTIMPDH2GAA | |
| SCHEMBL7753765 | 0.87 | KMT2A (0.41) | KMT2AMAPTIMPDH2GAAADCY8 | |
| SCHEMBL7753761 | 0.87 | KMT2A (0.41) | KMT2AMAPTIMPDH2GAAADCY8 | |
| SCHEMBL7753800 | 0.83 | KMT2A (0.57) | KMT2AKIF11MAPTCRHR1GAA | |
| SCHEMBL4037230 | 0.79 | KMT2A (0.72) | KMT2AMAPTIMPDH2GAAMAPK1 | |
| SCHEMBL7759728 | 0.77 | TMPRSS4 (0.43) | MAPTGAAMAPK1EPHX2TMPRSS4 | |
| SCHEMBL2088566 | 0.77 | KMT2A (0.59) | KMT2AMAPTIMPDH2MAPK1KDM4E | |
| SCHEMBL2088564 | 0.77 | KMT2A (0.59) | KMT2AMAPTIMPDH2MAPK1KDM4E | |
| SCHEMBL2087129 | 0.76 | KMT2A (0.80) | KMT2AMAPTIMPDH2GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077933-A1 | SUBSTITUTED GUANIDINES AND DIAMINONITROETHENES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2001-02-28 | — | — | EP | disclosed |
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | disclosed |
| WO-1999058497-A1 | SUBSTITUTED GUANIDINES AND DIAMINONITROETHENES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-11-18 | — | — | WO | disclosed |