Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760074 | 1.00 | NR3C1 (0.51) | NR3C1PTGESFFAR1 | |
| SCHEMBL8496617 | 1.00 | NR3C1 (0.51) | NR3C1PTGESFFAR1 | |
| SCHEMBL8826146 | 1.00 | NR3C1 (0.51) | NR3C1PTGESFFAR1 | |
| SCHEMBL8826152 | 1.00 | NR3C1 (0.51) | NR3C1PTGESFFAR1 | |
| SCHEMBL8492532 | 1.00 | NR3C1 (0.51) | NR3C1PTGESFFAR1 | |
| SCHEMBL8826173 | 0.98 | NR3C1 (0.49) | NR3C1FFAR1 | |
| SCHEMBL8496846 | 0.98 | NR3C1 (0.49) | NR3C1FFAR1 | |
| SCHEMBL8496842 | 0.98 | NR3C1 (0.49) | NR3C1FFAR1 | |
| SCHEMBL8826170 | 0.98 | NR3C1 (0.49) | NR3C1FFAR1 | |
| SCHEMBL8496847 | 0.98 | NR3C1 (0.49) | NR3C1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090908-A2 | Cyclobutane derivatives as inhibitors of protein farnesyltransferase | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | claimed |
| EP-0821665-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1998-02-04 | — | — | EP | claimed |
| WO-1996033159-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-10-24 | — | — | WO | claimed |
| EP-0821665-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1090908-A2 | Cyclobutane derivatives as inhibitors of protein farnesyltransferase | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-0821665-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033159-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-10-24 | — | — | WO | disclosed |