Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.60 |
| ▸ | FLT1 | P17948 | 6/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.60 |
| ▸ | RAF1 | P04049 | 2/20 | 0.57 |
| ▸ | BRAF | P15056 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 7/20 | 0.52 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | KIF5B | P33176 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763519 | 0.83 | EGFR (0.56) | KDRRAF1BRAFEGFRFLT4 | |
| SCHEMBL8308072 | 0.81 | EGFR (0.49) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL7760849 | 0.80 | EGFR (0.68) | KDRRAF1BRAFEGFRFLT4 | |
| SCHEMBL2101849 | 0.77 | EGFR (0.67) | EGFRERBB2ALDH1A1LMNAMAPK1 | |
| SCHEMBL7766135 | 0.75 | FGFR1 (0.62) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL5959016 | 0.75 | KDR (0.61) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL7763501 | 0.74 | EGFR (0.66) | KDRRAF1BRAFEGFRFLT4 | |
| Hydrochloric Acid SCHEMBL7215775 | 0.74 | KDR (0.60) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL15051770 | 0.72 | RAF1 (1.00) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL8684 | 0.72 | KDR (0.82) | KDRFLT1FGFR1RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824527-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-13 | — | — | EP | claimed |
| US-5942514-A | TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1999-08-24 | — | — | US | claimed |
| EP-0824527-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | claimed |
| WO-1996033979-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | claimed |
| EP-0824527-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-13 | — | — | EP | disclosed |
| US-5942514-A | TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1999-08-24 | — | — | US | disclosed |
| EP-0824527-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033979-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |