Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.82 |
| ▸ | FLT1 | P17948 | 5/20 | 0.82 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.82 |
| ▸ | RAF1 | P04049 | 3/20 | 0.75 |
| ▸ | BRAF | P15056 | 3/20 | 0.75 |
| ▸ | EGFR | P00533 | 5/20 | 0.67 |
| ▸ | RET | P07949 | 10/20 | 0.66 |
| ▸ | KIF5B | P33176 | 9/20 | 0.66 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241456 | 0.90 | KDR (0.83) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL24714001 | 0.86 | BRAF (0.63) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL15051770 | 0.86 | RAF1 (1.00) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL2055589 | 0.85 | RAF1 (0.76) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL156289 | 0.85 | KDR (0.83) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL14964757 | 0.84 | EGFR (0.81) | KDRFLT1RAF1BRAFEGFR | |
| SCHEMBL13617351 | 0.84 | KDR (0.65) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL1467058 | 0.84 | KDR (0.83) | KDRFLT1FGFR1RAF1BRAF | |
| Hydrochloric Acid SCHEMBL28007000 | 0.84 | KDR (0.81) | KDRFLT1FGFR1RAF1BRAF | |
| SCHEMBL18158611 | 0.83 | KDR (0.82) | KDRFLT1FGFR1EGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823900-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-12-27 | — | — | EP | disclosed |
| US-5770599-A | RECEPTOR TYROSINE KINASE INHIBITORS including 4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(2-morpholinoethoxy)quinazoline (gefitinib) | ZENECA LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| EP-0823900-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996033980-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |