Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.64 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27819297 | 0.83 | EGFR (0.74) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL7764438 | 0.83 | EGFR (0.62) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL2248477 | 0.83 | EGFR (0.77) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL2255586 | 0.82 | EGFR (0.74) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL16693868 | 0.81 | EGFR (0.67) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL2250814 | 0.80 | EGFR (0.68) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL6186109 | 0.80 | EGFR (0.71) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL6188789 | 0.79 | EGFR (0.80) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL2245963 | 0.79 | EGFR (0.66) | EGFRAURKBERBB2ERBB4HDAC3 | |
| SCHEMBL5497185 | 0.79 | EGFR (0.72) | EGFRAURKBERBB2ERBB4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824527-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-13 | — | — | EP | disclosed |
| US-5942514-A | TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1999-08-24 | — | — | US | disclosed |
| EP-0824527-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033979-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |