Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.62 |
| ▸ | FBP1 | P09467 | 2/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760849 | 0.89 | EGFR (0.68) | EGFRFBP1ERBB2AURKAINSR | |
| SCHEMBL7763501 | 0.85 | EGFR (0.66) | EGFRFBP1ERBB2AURKAINSR | |
| SCHEMBL7760716 | 0.83 | EGFR (0.70) | EGFRERBB2AURKBHDAC3HDAC4 | |
| SCHEMBL25083284 | 0.81 | EGFR (0.71) | EGFRFBP1ERBB2AURKAINSR | |
| SCHEMBL17538563 | 0.81 | EGFR (0.63) | EGFRFBP1ERBB2AURKAINSR | |
| SCHEMBL7763519 | 0.79 | EGFR (0.56) | EGFRFBP1ERBB2AURKAINSR | |
| SCHEMBL21083167 | 0.79 | EGFR (0.75) | EGFRFBP1ERBB2AURKAINSR | |
| SCHEMBL17538541 | 0.78 | EGFR (0.61) | EGFRFBP1ERBB2AURKAINSR | |
| SCHEMBL27797818 | 0.78 | EGFR (0.75) | EGFRFBP1ERBB2AURKAINSR | |
| SCHEMBL6188729 | 0.77 | EGFR (0.77) | EGFRFBP1ERBB2AURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824527-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-13 | — | — | EP | disclosed |
| US-5942514-A | TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1999-08-24 | — | — | US | disclosed |
| EP-0824527-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033979-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |