Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 3/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5379743 | 1.00 | KLK5 (0.57) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL5379746 | 1.00 | KLK5 (0.57) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL5393279 | 0.97 | KLK5 (0.56) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL5393283 | 0.97 | KLK5 (0.56) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL5379408 | 0.96 | KLK5 (0.55) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL5379412 | 0.96 | KLK5 (0.55) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL5223896 | 0.93 | KLK5 (0.59) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL5223891 | 0.93 | KLK5 (0.59) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL7309908 | 0.90 | KLK5 (0.65) | KLK5ATMBCHECTSKBACE1 | |
| SCHEMBL5218236 | 0.89 | KLK5 (0.56) | KLK5ATMBCHEBACE1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769003-B1 | AMINO ACID-DERIVED DIAMINOPROPANOLS | PHARMECO LAB INC (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1059285-A2 | Process for the preparation of 1,3-diamino-2-propanol and 1,3-diamino-2-propanone derivatives | Pharm-Eco Laboratories, Inc. (US) | 2000-12-13 | — | — | EP | disclosed |
| US-6063963-A | Amino acid-derived diaminopropanols | PHARM-ECO LABORATORIES, INC. (US) | 2000-05-16 | — | — | US | disclosed |
| US-5631405-A | Method of forming amino acid-derived diaminopropanols useful as chemical intermediates for protease-inhibitors | PHARM-ECO LABORATORIES, INCORPORATED (US) | 1997-05-20 | — | — | US | disclosed |
| US-5618966-A | Method forming protease inhibitor synthetic intermediates | PHARM-ECO LABORATORIES, INCORPORATED (US) | 1997-04-08 | — | — | US | disclosed |
| US-5599994-A | Amino acid-derived diaminopropanols | PHARM-ECO LABORATORIES, INC. (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996001788-A2 | AMINO ACID-DERIVED DIAMINOPROPANOLS | PHARM-ECO LABORATORIES, INCORPORATED (US) | 1996-01-25 | — | — | WO | disclosed |
| US-5475138-A | Method preparing amino acid-derived diaminopropanols | PHARM-ECO LABORATORIES INCORPORATED (US) | 1995-12-12 | — | — | US | disclosed |