Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.60 |
| ▸ | MMP8 | P22894 | 4/20 | 0.51 |
| ▸ | MMP13 | P45452 | 4/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239549 | 1.00 | MMP1 (0.60) | MMP1ADAM17MMP8MMP13MMP3 | |
| SCHEMBL6237402 | 0.91 | MMP1 (0.71) | MMP1ADAM17MMP8MMP13MMP3 | |
| SCHEMBL6239380 | 0.84 | MMP1 (0.58) | MMP1ADAM17MMP8MMP13MMP3 | |
| SCHEMBL7765006 | 0.82 | MMP1 (0.54) | MMP1ADAM17MMP8MMP13MMP3 | |
| SCHEMBL6237732 | 0.82 | MMP1 (0.54) | MMP1ADAM17MMP8MMP13MMP3 | |
| SCHEMBL6241314 | 0.82 | MMP1 (0.54) | MMP1ADAM17MMP8MMP13MMP3 | |
| SCHEMBL6236919 | 0.82 | MMP1 (0.54) | MMP1ADAM17MMP8MMP13MMP3 | |
| SCHEMBL6238546 | 0.81 | MMP1 (0.55) | MMP1ADAM17MMP13 | |
| SCHEMBL7761414 | 0.81 | MMP1 (0.55) | MMP1ADAM17MMP13 | |
| SCHEMBL5756703 | 0.81 | MMP1 (0.81) | MMP1ADAM17MMP8MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104412-A1 | TACE INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009492-A1 | TACE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |