Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.52 |
| ▸ | PPARG | P37231 | 7/20 | 0.52 |
| ▸ | PPARD | Q03181 | 7/20 | 0.52 |
| ▸ | PPARA | Q07869 | 7/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11138068 | 0.97 | GPR84 (0.50) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL28085708 | 0.92 | GPR84 (0.50) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL28133734 | 0.92 | GPR84 (0.50) | GPR84PPARGPPARDPPARAHDAC11 | |
| Acetic Acid SCHEMBL27468259 | 0.92 | GPR84 (0.50) | GPR84PPARGPPARDPPARAHDAC11 | |
| Acetic Acid SCHEMBL4440183 | 0.92 | GPR84 (0.50) | GPR84PPARGPPARDPPARAHDAC11 | |
| Hexanethiol SCHEMBL28115341 | 0.92 | GPR84 (0.50) | GPR84PPARGPPARDPPARAHDAC11 | |
| Acetic Acid SCHEMBL9682702 | 0.92 | GPR84 (0.50) | GPR84PPARGPPARDPPARAHDAC11 | |
| Hydrogen Peroxide SCHEMBL3127404 | 0.91 | TSHR (0.53) | GPR84PPARGPPARDPPARAHDAC11 | |
| Propionic Acid SCHEMBL9064379 | 0.90 | GPR84 (0.54) | GPR84PPARGPPARDPPARAHDAC11 | |
| Propionic Acid SCHEMBL15737687 | 0.90 | GPR84 (0.54) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778822-B1 | NOVEL POLYOL ESTERS OF ETHER CARBOXYLIC ACIDS AND FIBER FINISHING METHODS | COGNIS DEUTSCHLAND GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0778822-A4 | NOVEL POLYOL ESTERS OF ETHER CARBOXYLIC ACIDS AND FIBER FINISHING METHODS | HENKEL CORP (US) | 1997-11-19 | — | — | EP | disclosed |
| US-5654038-A | FIBER FINISHES HAVING HEAT RESISTANCE, WATER SOLUBILITY/DISPERSION AND VISCOSITY/MATERIALS HANDLING; LUBRICANTS | HENKEL CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0778822-A1 | NOVEL POLYOL ESTERS OF ETHER CARBOXYLIC ACIDS AND FIBER FINISHING METHODS | HENKEL CORPORATION (US) | 1997-06-18 | — | — | EP | disclosed |
| US-5576470-A | Polyol esters of ether carboxylic acids and fiber finishing methods | HENKEL CORPORATION (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1996006824-A1 | NOVEL POLYOL ESTERS OF ETHER CARBOXYLIC ACIDS AND FIBER FINISHING METHODS | HENKEL CORPORATION (US) | 1996-03-07 | — | — | WO | disclosed |