Sugi Predict

Sugi Predict / Compounds / SCHEMBL7762075

SCHEMBL7762075

SCHEMBL7762075

O=Cc1ccc(F)c(Cl)c1F

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 2/20 0.45
▸ ERN1 O75460 8/20 0.42
▸ HSD17B10 Q99714 1/20 0.41
▸ MEN1 O00255 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ THRB P10828 1/20 0.35
▸ BLM P54132 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ NFE2L2 Q16236 1/20 0.34
▸ KCNJ1 P48048 1/20 0.33
▸ TNF P01375 1/20 0.32
▸ RIPK1 Q13546 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1807912 0.86 TDP1 (0.43) TDP1ERN1HSD17B10MEN1LMNA
SCHEMBL6495322 0.84 TDP1 (0.46) TDP1ERN1HSD17B10MEN1LMNA
SCHEMBL6904097 0.82 TDP1 (0.45) TDP1ERN1HSD17B10MEN1LMNA
SCHEMBL15514624 0.82 TDP1 (0.45) TDP1ERN1HSD17B10MEN1LMNA
SCHEMBL23748183 0.78 ERN1 (0.59) TDP1ERN1
SCHEMBL17842808 0.78 ALDH1A1 (0.40) TDP1ERN1HSD17B10MEN1LMNA
SCHEMBL29955337 0.78 ERN1 (0.59) TDP1ERN1
SCHEMBL13743748 0.78 TDP1 (0.38) TDP1ERN1HSD17B10MEN1LMNA
SCHEMBL29954266 0.78 ERN1 (0.48) TDP1ERN1MEN1KMT2A
SCHEMBL18795651 0.78 TDP1 (0.38) TDP1ERN1HSD17B10MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0347692-B1 PROCESS FOR PREPARING FLUOR-SUBSTITUTED BENZALDEHYDES BASF Aktiengesellschaft (DE) 1992-08-26 — — EP claimed
EP-0347692-A1 Process for preparing fluor-substituted benzaldehydes BASF Aktiengesellschaft (DE) 1989-12-27 — — EP claimed
US-12545685-B2 Dispiropyrrolidine derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2026-02-10 — — US disclosed
US-12516046-B2 2-oxo-oxazolidine-5-carboxamides as NAV1.8 inhibitors MERCK SHARP & DOHME LLC (US) 2026-01-06 — — US disclosed
US-20250243183-A1 IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS INCYTE CORPORATION 2025-07-31 — — US disclosed
WO-2025125665-A1 FURTHER SUBSTITUTED IMIDAZOLES AS INHIBITORS OF NAV1.8 Grünenthal GmbH (DE) 2025-06-19 — — WO disclosed
US-12312331-B2 Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors INCYTE CORPORATION (US) 2025-05-27 — — US disclosed
WO-2024259241-A1 5-HT2A RECEPTOR MODULATORS AND METHODS OF USE THEREOF Transneural Therapeutics, Inc. (US) 2024-12-19 — — WO disclosed
US-20240246989-A1 DISPIROPYRROLIDINE DERIVATIVES DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-07-25 — — US disclosed
US-11802122-B2 2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors MERCK SHARP & DOHME LLC (US) 2023-10-31 — — US disclosed
US-20230312528-A1 2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS MERCK SHARP & DOHME LLC (US) 2023-10-05 — — US disclosed
US-20130165424-A9 DISPIROPYRROLIDINE DERIVATIVES DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-06-27 — — US disclosed
US-20130165424-A9 DISPIROPYRROLIDINE DERIVATIVES DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-06-27 — — US disclosed
US-20120264738-A1 DISPIROPYRROLIDINE DERIVATIVES SUGIMOTO YUUICHI (JP) 2012-10-18 — — US disclosed
US-20120264738-A1 DISPIROPYRROLIDINE DERIVATIVES SUGIMOTO YUUICHI (JP) 2012-10-18 — — US disclosed
US-20120264738-A1 DISPIROPYRROLIDINE DERIVATIVES SUGIMOTO YUUICHI (JP) 2012-10-18 — — US disclosed
WO-2012121361-A1 DISPIROPYRROLIDINE DERIVATIVE 第一三共株式会社 (JP) 2012-09-13 — — WO disclosed
EP-1101752-A2 Process for the preparation of halogenated benzyl alcohols Clariant GmbH (DE) 2001-05-23 — — EP disclosed
EP-0347692-B1 PROCESS FOR PREPARING FLUOR-SUBSTITUTED BENZALDEHYDES BASF Aktiengesellschaft (DE) 1992-08-26 — — EP disclosed
EP-0347692-A1 Process for preparing fluor-substituted benzaldehydes BASF Aktiengesellschaft (DE) 1989-12-27 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120264738-A1 DISPIROPYRROLIDINE DERIVATIVES MDM2, TP53, TP53BP1 TDP1 1524/4885ERN1 2514/4885HSD17B10 2944/4885
US-12312331-B2 Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors CDK2, CDK4, CDK2AP2 TDP1 1699/4885ERN1 703/4885HSD17B10 4313/4885
US-12545685-B2 Dispiropyrrolidine derivatives TP53, MDM2, TP53BP1 TDP1 872/4885ERN1 1336/4885HSD17B10 2895/4885
US-11802122-B2 2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors SCN8A, TRPV1, SCN2A TDP1 4129/4885ERN1 2455/4885HSD17B10 4178/4885
US-20240246989-A1 DISPIROPYRROLIDINE DERIVATIVES MDM2, TP53, TP53BP1 TDP1 1524/4885ERN1 2514/4885HSD17B10 2944/4885
US-20130165424-A9 DISPIROPYRROLIDINE DERIVATIVES MDM2, TP53, TP53BP1 TDP1 1524/4885ERN1 2514/4885HSD17B10 2944/4885
US-20250243183-A1 IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS CDK2, CDK4, CDK2AP2 TDP1 1699/4885ERN1 703/4885HSD17B10 4313/4885
US-20230312528-A1 2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS SCN8A, TRPV1, SCN2A TDP1 4038/4885ERN1 2532/4885HSD17B10 4205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.