SCHEMBL7762178

SCHEMBL7762178

O=C1C(CSCc2ccccc2)CC(CSCc2ccccc2)N1Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 1/20 0.46
EHMT2 Q96KQ7 1/20 0.43
ALDH1A1 P00352 7/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
LMNA P02545 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
HTT P42858 2/20 0.41
KMT2A Q03164 2/20 0.41
NPC1 O15118 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
RAB9A P51151 1/20 0.40
ATM Q13315 1/20 0.40
TSHR P16473 2/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C19 P33261 1/20 0.40
SMO Q99835 2/20 0.36
MEN1 O00255 1/20 0.36
AGTR2 P50052 1/20 0.36
PSMD14 O00487 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7767518 0.87 CRBN (0.41) CRBNEHMT2ALDH1A1SMN1; SMN2LMNA
SCHEMBL7767480 0.86 CRBN (0.40) CRBNEHMT2ALDH1A1SMN1; SMN2LMNA
SCHEMBL7762198 0.84 CRBN (0.39) CRBNEHMT2ALDH1A1SMN1; SMN2LMNA
SCHEMBL7767479 0.84 CRBN (0.39) CRBNEHMT2ALDH1A1SMN1; SMN2LMNA
SCHEMBL7765837 0.84 EHMT2 (0.39) EHMT2ALDH1A1SMN1; SMN2LMNAL3MBTL1
SCHEMBL7764939 0.82 EHMT2 (0.44) EHMT2ALDH1A1SMN1; SMN2KMT2AGAA
SCHEMBL7765779 0.79 CRBN (0.40) CRBNEHMT2ALDH1A1SMN1; SMN2LMNA
SCHEMBL7766806 0.79 CRBN (0.40) CRBNEHMT2ALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL7762226 0.79 CRBN (0.40) CRBNEHMT2ALDH1A1SMN1; SMN2LMNA
SCHEMBL7764959 0.78 CRBN (0.44) CRBNALDH1A1SMN1; SMN2LMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0639566-B1 CYCLIC COMPOUND SANTEN PHARMACEUTICAL CO LTD (JP) 2001-06-20 EP disclosed
US-5461158-A Immunodeficiency and autoimmune diseases SANTEN PHARMACEUTICAL CO., LTD. (JP) 1995-10-24 US disclosed
EP-0639566-A1 CYCLIC COMPOUND SANTEN PHARMACEUTICAL CO., LTD. (JP) 1995-02-22 EP disclosed