Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762178 | 0.84 | CRBN (0.46) | EHMT2TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL7764939 | 0.78 | EHMT2 (0.44) | EHMT2TSHRCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7764893 | 0.74 | CRBN (0.36) | EHMT2TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL7283610 | 0.74 | EHMT2 (0.41) | EHMT2TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL7273849 | 0.74 | TSHR (0.41) | EHMT2TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL7765831 | 0.73 | ACE (0.44) | EHMT2TSHRCYP3A4CYP2C19SMO | |
| SCHEMBL7767518 | 0.73 | CRBN (0.41) | EHMT2TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL7766834 | 0.72 | CYP2C19 (0.40) | EHMT2TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL7767480 | 0.72 | CRBN (0.40) | EHMT2TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL7767479 | 0.71 | CRBN (0.39) | EHMT2TSHRCYP3A4CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639566-B1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5461158-A | Immunodeficiency and autoimmune diseases | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0639566-A1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-02-22 | — | — | EP | disclosed |