Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307081 | 0.67 | HTT (0.39) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL9493901 | 0.65 | — | — | |
| SCHEMBL576066 | 0.65 | POLB (0.56) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL7762186 | 0.64 | POLB (0.41) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL7767198 | 0.62 | CRBN (0.49) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL8029112 | 0.62 | HTT (0.53) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL7767499 | 0.62 | POLB (0.31) | POLB | |
| SCHEMBL20968646 | 0.60 | POLB (0.51) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL576794 | 0.60 | KMT2A (0.56) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL9033045 | 0.60 | POLB (0.37) | POLBKMT2AMEN1HTTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639566-B1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5461158-A | Immunodeficiency and autoimmune diseases | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0639566-A1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-02-22 | — | — | EP | disclosed |