Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767486 | 1.00 | POLB (0.37) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL7767455 | 0.85 | KMT2A (0.36) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL7769357 | 0.82 | ALDH1A1 (0.37) | POLBKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL576066 | 0.68 | POLB (0.56) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL576794 | 0.64 | KMT2A (0.56) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL20968646 | 0.64 | POLB (0.51) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL9450639 | 0.64 | PRSS1 (0.39) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL9450611 | 0.64 | PRSS1 (0.39) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL9450640 | 0.64 | PRSS1 (0.39) | POLBKMT2AMEN1HTTCYP2C9 | |
| SCHEMBL14973545 | 0.63 | KMT2A (0.60) | KMT2AMEN1HTTCYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558287-B1 | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO LTD (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5292767-A | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0558287-A1 | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |