SCHEMBL7762876

SCHEMBL7762876

CCN(CC)CCNc1ncccc1-c1nc2c(OC(N)=O)cccc2[nH]1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 2/20 0.46
GSK3A P49840 2/20 0.46
DYRK1A Q13627 2/20 0.46
PIM3 Q86V86 2/20 0.46
AURKB Q96GD4 2/20 0.46
CLK4 Q9HAZ1 2/20 0.46
PRKD3 O94806 1/20 0.46
PRKCG P05129 1/20 0.46
RPS6KA3 P51812 1/20 0.46
PRKCD Q05655 1/20 0.46
BRSK1 Q8TDC3 1/20 0.46
MKNK2 Q9HBH9 1/20 0.46
CHEK1 O14757 1/20 0.44
MAP4K4 O95819 1/20 0.44
LCK P06239 1/20 0.44
CSF1R P07333 1/20 0.44
PHKG2 P15735 1/20 0.44
MARK3 P27448 1/20 0.44
KDR P35968 1/20 0.44
FLT3 P36888 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6585041 0.99 PIM1 (0.45) PIM1GSK3ADYRK1APIM3AURKB
SCHEMBL6587676 0.95 PIM1 (0.53) PIM1GSK3ADYRK1APIM3AURKB
SCHEMBL6587470 0.91 PDE5A (0.43) PIM1GSK3ADYRK1APIM3AURKB
SCHEMBL6590811 0.88 PIM1 (0.42) PIM1GSK3ADYRK1APIM3AURKB
Hydrochloric Acid SCHEMBL6803487 0.85 PIM1 (0.61) PIM1GSK3ADYRK1APIM3AURKB
SCHEMBL7764199 0.84 PIM1 (0.55) PIM1GSK3ADYRK1APIM3AURKB
Hydrochloric Acid SCHEMBL6587717 0.84 PIM1 (0.54) PIM1GSK3ADYRK1APIM3AURKB
SCHEMBL7765899 0.83 PIM1 (0.44) PIM1GSK3ADYRK1APIM3AURKB
SCHEMBL6586664 0.83 PIM1 (0.67) PIM1GSK3ADYRK1APIM3AURKB
Hydrochloric Acid SCHEMBL6588235 0.82 PIM1 (0.44) PIM1GSK3ADYRK1APIM3AURKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001082877-A2 USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS BASF AKTIENGESELLSCHAFT (DE) 2001-11-08 WO disclosed