Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP7 | O15540 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762918 | 1.00 | FABP7 (0.46) | FABP7FABP5PTGESLPAR1LPAR5 | |
| SCHEMBL7761033 | 1.00 | FABP7 (0.46) | FABP7FABP5PTGESLPAR1LPAR5 | |
| SCHEMBL7761028 | 1.00 | FABP7 (0.46) | FABP7FABP5PTGESLPAR1LPAR5 | |
| SCHEMBL7760093 | 0.91 | FABP7 (0.49) | FABP7FABP5 | |
| SCHEMBL7761974 | 0.91 | FABP7 (0.49) | FABP7FABP5 | |
| SCHEMBL7761978 | 0.91 | FABP7 (0.49) | FABP7FABP5 | |
| SCHEMBL7760087 | 0.91 | FABP7 (0.49) | FABP7FABP5 | |
| SCHEMBL7760080 | 0.90 | PTGES (0.46) | PTGESLPAR1LPAR5NR3C1 | |
| SCHEMBL7756969 | 0.90 | PTGES (0.46) | PTGESLPAR1LPAR5NR3C1 | |
| SCHEMBL7760085 | 0.90 | PTGES (0.46) | PTGESLPAR1LPAR5NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821665-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1090908-A2 | Cyclobutane derivatives as inhibitors of protein farnesyltransferase | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | disclosed |