Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17623899 | 0.83 | PDE2A (0.49) | PDE2AHTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17608918 | 0.83 | PDE2A (0.49) | PDE2AHTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19317586 | 0.81 | PDE2A (0.47) | PDE2AHTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30215796 | 0.75 | PDE2A (0.71) | PDE2AHTTSLC6A3ALDH1A1MEN1 | |
| SCHEMBL10272488 | 0.74 | LMNA (0.47) | ALDH1A1LMNATDP1MEN1MAPT | |
| SCHEMBL6343990 | 0.74 | LMNA (0.43) | ALDH1A1LMNATDP1L3MBTL1NPC1 | |
| SCHEMBL5229072 | 0.74 | BRD4 (0.49) | PDE2AHTTALDH1A1LTA4HBRD4 | |
| SCHEMBL10846707 | 0.73 | LMNA (0.46) | ALDH1A1LMNATDP1MEN1MAPT | |
| SCHEMBL16815455 | 0.73 | LMNA (0.50) | ALDH1A1LMNATDP1L3MBTL1NPC1 | |
| SCHEMBL1569182 | 0.73 | BRD4 (0.62) | PDE2AHTTALDH1A1MAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097143-A1 | METHOD FOR PREPARING 5-(1-METHYLETHYL)-6-(PHENYLMETHYL)PYRIMIDINE-2,4(1H,3H)-DIONE | FINORGA SA (FR) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003999-A1 | METHOD FOR PREPARING 5-(1-METHYLETHYL)-6-(PHENYLMETHYL)PYRIMIDINE-2,4(1H,3H)-DIONE | SANOFI-SYNTHELABO (FR) | 2000-01-27 | — | — | WO | disclosed |