Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.64 |
| ▸ | HTR7 | P34969 | 3/20 | 0.64 |
| ▸ | DRD2 | P14416 | 2/20 | 0.64 |
| ▸ | HTR1D | P28221 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | HTR5A | P47898 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8903804 | 0.99 | HTR1A (0.62) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL9758851 | 0.89 | HTR1A (0.62) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL9183801 | 0.88 | HTR1A (0.61) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL8904245 | 0.88 | HTR1A (0.70) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL7763436 | 0.86 | HTR1A (0.68) | HTR1AHTR7DRD2HTR1DDRD3 | |
| Hydrochloric Acid SCHEMBL8904219 | 0.86 | HTR1A (0.68) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL7768623 | 0.86 | HTR1A (0.61) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL7932899 | 0.85 | HTR1A (0.67) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL7768095 | 0.85 | HTR1A (0.67) | HTR1AHTR7DRD2HTR1DDRD3 | |
| Hydrochloric Acid SCHEMBL8822572 | 0.85 | HTR1A (0.67) | HTR1AHTR7DRD2HTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579507-B1 | Isoxazole derivatives for the treatment of irritable bowel syndrome | LILLY CO ELI (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-0712837-B1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | LILLY CO ELI (US) | 2000-10-25 | — | — | EP | disclosed |
| EP-0498590-B1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes | LILLY CO ELI (US) | 1997-04-09 | — | — | EP | disclosed |
| US-5571942-A | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes | ELI LILLY AND COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0712837-A2 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | ELI LILLY AND COMPANY (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5434174-A | Administering 5-hydroxytryptamine agonist; gastrointestinal disorders | ELI LILLY AND COMPANY (US) | 1995-07-18 | — | — | US | disclosed |
| US-5426226-A | Intermediates for making ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes | HOECHSTETTER CRAIG S (US) | 1995-06-20 | — | — | US | disclosed |
| US-5389687-A | Selective antagonists of serotonin | ELI LILLY AND COMPANY (US) | 1995-02-14 | — | — | US | disclosed |
| EP-0579507-A1 | Isoxazole derivatives for the treatment of irritable bowel syndrome | ELI LILLY AND COMPANY (US) | 1994-01-19 | — | — | EP | disclosed |
| EP-0498590-A1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |