Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | STK17B | O94768 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629162 | 0.92 | EGFR (0.79) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL7766270 | 0.87 | EGFR (0.72) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL7770429 | 0.86 | EGFR (0.72) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL7763501 | 0.81 | EGFR (0.66) | EGFRERBB2BRAFFLT4KDR | |
| SCHEMBL26066963 | 0.81 | EGFR (0.52) | EGFRERBB2ERBB4HRH3 | |
| SCHEMBL12012 | 0.80 | EGFR (1.00) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL17520338 | 0.80 | EGFR (1.00) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL11395 | 0.79 | EGFR (1.00) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL17520333 | 0.79 | EGFR (0.95) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL3578798 | 0.79 | EGFR (0.77) | EGFRERBB2ERBB4CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824526-B1 | QUINAZOLINE DERIVATIVE | ASTRAZENECA AB (SE) | 2001-06-13 | — | — | EP | claimed |
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | claimed |
| EP-0824526-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | claimed |
| WO-1996033978-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | claimed |
| EP-0824526-B1 | QUINAZOLINE DERIVATIVE | ASTRAZENECA AB (SE) | 2001-06-13 | — | — | EP | disclosed |
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | disclosed |
| EP-0824526-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033978-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |