Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.63 |
| ▸ | BRAF | P15056 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7766270 | 0.99 | EGFR (0.72) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7766288 | 0.91 | EGFR (0.73) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7763487 | 0.86 | EGFR (0.70) | EGFRERBB2BRAFKDRCIT | |
| SCHEMBL27797818 | 0.85 | EGFR (0.75) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11395 | 0.84 | EGFR (1.00) | EGFRERBB2BRAFKDRCIT | |
| SCHEMBL1151056 | 0.84 | EGFR (0.82) | EGFRERBB2BRAFKDRCIT | |
| Hydrochloric Acid SCHEMBL15565027 | 0.83 | EGFR (0.81) | EGFRERBB2BRAFKDRCIT | |
| SCHEMBL12012 | 0.83 | EGFR (1.00) | EGFRERBB2BRAFKDRCIT | |
| SCHEMBL17520338 | 0.83 | EGFR (1.00) | EGFRERBB2BRAFKDRCIT | |
| SCHEMBL7763005 | 0.82 | EGFR (0.61) | EGFRERBB2BRAFKDRCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824525-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-13 | — | — | EP | disclosed |
| US-5932574-A | ANTICANCER AGENT | ZENECA LIMITED (GB) | 1999-08-03 | — | — | US | disclosed |
| EP-0824525-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033977-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |