⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9550529 | 0.81 | SMN1; SMN2 (0.40) | — | |
| SCHEMBL10609347 | 0.81 | SMN1; SMN2 (0.40) | — | |
| SCHEMBL11489622 | 0.81 | — | — | |
| SCHEMBL30628125 | 0.76 | — | — | |
| SCHEMBL11175620 | 0.76 | — | — | |
| SCHEMBL10648033 | 0.74 | GLA (0.46) | — | |
| Potassium Ion SCHEMBL11003164 | 0.73 | GLA (0.41) | — | |
| SCHEMBL18282495 | 0.71 | RAB9A (0.49) | — | |
| SCHEMBL9977875 | 0.69 | NPC1 (0.37) | — | |
| SCHEMBL11010760 | 0.69 | HPGD (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4460307-A1 | 2,3-DIHYDROBENZO [B][1, 4]DIOXIN-2-YLMETHYL)PIPERAZIN-1-YL DERIVATES FOR THE TREATMENT OF SLEEP APNEA | Bayer Aktiengesellschaft (DE) | 2024-11-13 | — | — | EP | claimed |
| WO-2023131638-A1 | 2,3-DIHYDROBENZO [B][1, 4]DIOXIN-2-YLMETHYL)PIPERAZIN-1-YL DERIVATES FOR THE TREATMENT OF SLEEP APNEA | BAYER AKTIENGESELLSCHAFT (DE) | 2023-07-13 | — | — | WO | claimed |
| EP-3600312-B1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICALS CO (JP) | 2023-05-17 | — | — | EP | claimed |
| EP-4460307-A1 | 2,3-DIHYDROBENZO [B][1, 4]DIOXIN-2-YLMETHYL)PIPERAZIN-1-YL DERIVATES FOR THE TREATMENT OF SLEEP APNEA | Bayer Aktiengesellschaft (DE) | 2024-11-13 | — | — | EP | disclosed |
| EP-4249480-A1 | DIPHENYLPYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Northwest A&F University (CN) | 2023-09-27 | — | — | EP | disclosed |
| WO-2023131638-A1 | 2,3-DIHYDROBENZO [B][1, 4]DIOXIN-2-YLMETHYL)PIPERAZIN-1-YL DERIVATES FOR THE TREATMENT OF SLEEP APNEA | BAYER AKTIENGESELLSCHAFT (DE) | 2023-07-13 | — | — | WO | disclosed |
| WO-2001070228-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| EP-0099686-B1 | PROCESS FOR PREPARING POLYPIPERAZINAMIDE ANISOTROPIC MEMBRANES | Montedison S.p.A. (IT) | 1989-09-20 | — | — | EP | disclosed |